It is teaching action research intended to justify the choosing of Genetically Modified Organisms (GMOs) issue as an issue pontetial to create a disoerienting dilemma needed to produce a transformative learning and to identify its impact on the component of Reflection in the Ignatian Pedagogy model of teaching.A group of Farmacy stundnts taking the Neutraceutical class at sanata Dharma Universuty was chose as the case of this study.Based on the analysis of the collected data by using Liker score value judgment it is cllear that the choosing of GMOs issue as an issue potential to create a disorienting dilemma can be justified.It can be identiified also that its impact on the component of Reflection takes the forms of 1) the creating of disorienting dilemma experience which can produce a trasformative learning 2) the increasing of the judgment ability of the student and 3) the meeting of the specific target intended by the lecturer which is that the students will have a more positive attitude toward Biotechnology and GMOs as the most promising means for developing Nutraceutical industry in the future.