Stroke is a serious public health issue and the main cause of disability and death after ischemic heart disease. Every year 12.2 million individuals worldwide suffer from a stroke which results in 6.5 million deaths. There has been an increasing incidence of stroke in Indonesia including in North Sulawesi. This study aims to examine the risk factors for stroke incidence in North Sulawesi in a population aged ge 35 years based on the 2018 Indonesia Basic Health Research data. This quantitative research was an analytical observational study with a cross-sectional design. The Chi-square test and multiple logistic regression were performed during data analysis involving 7 111 respondents. The multivariate analysis results showed that hypertension (p 0.000 AOR 8.739 95% CI 5.758-13.263) physical activity (p 0.000 AOR 2.771 95% CI 1.944-3.948) gender (p 0.000 AOR 2.047 95% CI 1.388-3.017) heart disease (p 0.015 AOR 1.919 95% CI 1.133-3.250) age (p 0.008 AOR 1.669 95% CI 1.144-2.434) occupation (p 0.008 AOR 1.693 95% CI 1.145-2.504) and fatty foods consumption (p 0.023 AOR 0.603 95% CI 0.390-0.932) had a significant correlation with stroke incidence in this study. The main finding of this study shows that hypertension is the most influential risk factor for stroke incidence in a population aged ge 35 years in North Sulawesi. Regular blood pressure screenings are needed as an early hypertension detection effort to prevent stroke incidence.