Abstract Indonesian students scientific literacy scores decreased by 13 points from PISA 2018 indicating that the scientific literacy skills of participants in Indonesia are low. One area of concern is students understanding of chemical equilibrium which is essential because it is a prerequisite for grasping subsequent materials. This study aims to assess the feasibility of interactive e-worksheets as a learning medium for chemical equilibrium material in terms of validity practicality and effectiveness. According to Thiagarajan the research employs the 4-D research and development model which includes Defining Designing Developing and Disseminating but is limited to the development stage. A limited trial was conducted using a one-group pretest-posttest research design. Validation results show that the interactive e-worksheet is valid with a mode value of 4 in content presentation language and design. The validity test results yielded a mode value 4 for both content and construct validity. The practicality test results indicated a high percentage of practicality with very practical criteria. The effectiveness test analysed using n-gain showed an n-gain value of 0.78 with high criteria and the paired sample t-test results indicated a P-value of 0.000 confirming that the post-test scores were significantly higher than the pretest scores. Thus the PBL-oriented Interactive e-worksheet can improve students scientific literacy skills. Keywords Science Literacy Skills Interactive E-LAPD Chemical Equlibrium